MRI study on MELAS neuro-myopathy
Since September 2014 we are carrying out a study on the use of advanced MRI (7-Tesla system) for visualization of neural abnormalities in MELAS.
The primary objectives of the study:
1. To identify cerebral abnormalities (cerebral biomarkers) in MELAS patients and to compared these with controls.
2. To compare cerebral abnormalities between MELAS patients without diabetes mellitus type II (DM-II) and MELAS patients with DM-II.
3. Multivariate data analyses to assess whether cerebral abnormalities and mutation load are associated with cognitive decrements in MELAS patients.
The study will be completed by the end of 2016.