MRI study on MELAS neuro-myopathy

Research type

Clinical research

Start date


Participating coworkers


MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is one of the major disease targets of Mi2Cure. MELAS, which is caused by defects in the mitochondria, can develop at any age and is associated with severe neurological defects, like epilepsy, dementia, migraine or psychiatric problems. Other defects (incl. cardiac failure, renal failure, diabetes, loss of hearing) often occur as well.

Description research

Since September 2014 we are carrying out a study on the use of advanced MRI (7-Tesla system) for visualization of neural abnormalities in MELAS.
The primary objectives of the study:
1. To identify cerebral abnormalities (cerebral biomarkers) in MELAS patients and to compared these with controls.
2. To compare cerebral abnormalities between MELAS patients without diabetes mellitus type II (DM-II) and MELAS patients with DM-II.
3. Multivariate data analyses to assess whether cerebral abnormalities and mutation load are associated with cognitive decrements in MELAS patients.
The study will be completed by the end of 2016.